Pharmaceuticals from Furfural
Example:
(2S)-phenyl-3-piperidone is an intermediate in the synthesis of compounds, which possess pharmacological activit. A group of researchers published in May 2014 their “efficient synthetic route towards tosyl-protected (2S)-phenyl-3-piperidone, a common intermediate for many drugs, has been developed in 5 steps with 54% yield from biomass derived furfural” [1]. The starting material for the synthesis was sun-dried rice straw, which was “collected from a rice straw farm in Jiangxi Province Fengcheng Area (China).
While at present the principal applications of furfural are seen to be as an extractant for lubricating oils, vegetable oils, and diesel fuel, as a fungicide, as a nematocide, and as the raw material for furfuryl alcohol to make foundry resins, other uses have been proven successfully on a multitude of fronts, and it is only a lack of research which prevents furfural and its derivatives from flooding the world in a stunning variety of different applications.[2]
Also see:
Other articles on dalinyebo.com that are related to ‘Pharma’
Map to Furfural and its many By-Products
Furfural and its many By-products
References:
[1] Teck Peng Loh, Peng-Fei Koh, Peng Wang and Jing-Mei Huang, Biomass Derived Furfural-Based Facile Synthesis of Protected (2S)-phenyl-3-piperidone, a Common Intermediate for Many Drugs, Chem. Commun., 2014, Accepted Manuscript (Supporting information, for our clients: downloads) [2] Introduction to the last chapter (“Odd Applications”) of the appendices in Karl Joachim Zeitsch, The Chemistry and Technology of Furfural and its Many By-Products; Sugar Series, Vol. 13; Elsevier: Amsterdam, 2000.Since 2001, DalinYebo provides knowhow:
To convert biomass to value added chemical products and applications that are used in industries such as steel, wood, pharmaceutical, automotive, agricultural chemicals, industrial chemicals, etc.
For the agri (biomass) processing, sugar, pulp&paper, etc. industries, we provide knowhow and technology to convert (residual) biomass to chemicals and energy.
For owners of biomass we offer technology and market access, creating investment opportunities in the cleantech space.
The essential technical challenge facing us, and the world in general, is the complete beneficiation of cellulosic material. We strive to provide viable and practical solution. Contact us to discuss the economic potential of your biomass.